Version 5.4
| Bos taurus Gene: BT.44411 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-643968.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | BT.44411 | ||||||||
| Gene Name | RAS guanyl-releasing protein 2 | ||||||||
| Synonyms | CalDAG-GEFI | ||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000001029 | ||||||||
| Encoded Proteins |
RAS guanyl-releasing protein 2
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000068831:
The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 29:43590193-43602499 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH |
TCR pathway
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| REACTOME |
Rap1 signalling pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
Effects of PIP2 hydrolysis pathway
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
FCERI mediated NF-kB activation pathway
Signaling by GPCR pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Adaptive Immune System pathway
Immune System pathway
Hemostasis pathway
GPCR downstream signaling pathway
Hemostasis pathway
Signaling by GPCR pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Effects of PIP2 hydrolysis pathway
Rap1 signalling pathway
Adaptive Immune System pathway
G alpha (q) signalling events pathway
Signal Transduction pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
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| KEGG |
MAPK signaling pathway pathway
Chemokine signaling pathway pathway
MAPK signaling pathway pathway
Chemokine signaling pathway pathway
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| INOH | |||||||||
| PID NCI |
TCR signaling in naïve CD8+ T cells
TCR signaling in naïve CD4+ T cells
Regulation of Ras family activation
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | F1MJ35 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 512056 | ||||||||
| UniGene | Bt.44411 | ||||||||
| RefSeq | NM_001099946 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | DAAA02063538 | ||||||||
| GenPept | |||||||||
| RNA Seq Atlas | 512056 | ||||||||