Version 5.4
| Homo sapiens Gene: RASGRP2 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-54498.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | RASGRP2 | ||||||||||||||||||
| Gene Name | RAS guanyl releasing protein 2 (calcium and DAG-regulated) | ||||||||||||||||||
| Synonyms | CALDAG-GEFI; CDC25L | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000068831 | ||||||||||||||||||
| Encoded Proteins |
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 11:64726911-64745456 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q13.1 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH |
TCR pathway
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| REACTOME |
Rap1 signalling pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
Effects of PIP2 hydrolysis pathway
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
FCERI mediated NF-kB activation pathway
Signaling by GPCR pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Adaptive Immune System pathway
Immune System pathway
Hemostasis pathway
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| KEGG |
MAPK signaling pathway pathway
Chemokine signaling pathway pathway
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| INOH | |||||||||||||||||||
| PID NCI |
TCR signaling in naïve CD8+ T cells
TCR signaling in naïve CD4+ T cells
Regulation of Ras family activation
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.99491 | ||||||||||||||||||
| RefSeq | NM_001098670 NM_001098671 NM_153819 XM_005273707 XM_006718411 XM_006718412 XM_006718413 XM_006718414 XM_006718415 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS31598 | ||||||||||||||||||
| HPRD | 09278 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||