Version 5.4
Bos taurus Gene: DNAJB2
Summary
InnateDB Gene IDBG-643989.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAJB2
Gene Name dnaJ homolog subfamily B member 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013782
Encoded Proteins
IDBP-696593
DnaJ (Hsp40) homolog, subfamily B, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135924:
This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:107949740-107957014
Strand Forward strand
Band
Transcripts
ENSBTAT00000018327 ENSBTAP00000018327
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030544 Hsp70 protein binding
GO:0031593 polyubiquitin binding
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
GO:0070628 proteasome binding
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0030308 negative regulation of cell growth
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0031398 positive regulation of protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042026 protein refolding
GO:0090084 negative regulation of inclusion body assembly
GO:0090086 negative regulation of protein deubiquitination
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016234 inclusion body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000135924
View Gene Order
ENSMUSG00000026203
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.13698
RefSeq NM_001034592
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca