InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DNAJB2

Summary

InnateDB Gene

IDBG-81509.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAJB2

Gene Name

DnaJ (Hsp40) homolog, subfamily B, member 2

Synonyms

DSMA5; HSJ-1; HSJ1; HSPF3

Species

Homo sapiens

Ensembl Gene

ENSG00000135924

Encoded Proteins

IDBP-81511

DnaJ (Hsp40) homolog, subfamily B, member 2

IDBP-246376

DnaJ (Hsp40) homolog, subfamily B, member 2

IDBP-246378

DnaJ (Hsp40) homolog, subfamily B, member 2

IDBP-389048

DnaJ (Hsp40) homolog, subfamily B, member 2

IDBP-389049

DnaJ (Hsp40) homolog, subfamily B, member 2

IDBP-389051

DnaJ (Hsp40) homolog, subfamily B, member 2

IDBP-389052

DnaJ (Hsp40) homolog, subfamily B, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:219279267-219286900

Strand

Forward strand

Band

q35

Transcripts

ENST00000336576	ENSP00000338019
ENST00000392087	ENSP00000375937
ENST00000392086	ENSP00000375936
ENST00000425450	ENSP00000414796
ENST00000421532	ENSP00000395173
ENST00000442681	ENSP00000392790
ENST00000439026	ENSP00000387951
ENST00000480537
ENST00000477917
ENST00000482988
ENST00000481815
ENST00000485220
ENST00000463463
ENST00000487855
ENST00000473750
ENST00000472019
ENST00000476254
ENST00000470530

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030544	Hsp70 protein binding
GO:0031593	polyubiquitin binding
GO:0051082	unfolded protein binding
GO:0051087	chaperone binding
GO:0070628	proteasome binding

Biological Process

GO:0006457	protein folding
GO:0006986	response to unfolded protein
GO:0008219	cell death
GO:0008285	negative regulation of cell proliferation
GO:0030308	negative regulation of cell growth
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0031398	positive regulation of protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042026	protein refolding
GO:0090084	negative regulation of inclusion body assembly
GO:0090086	negative regulation of protein deubiquitination

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005829	cytosol
GO:0016234	inclusion body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026203

View Gene Order

ENSBTAG00000013782

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.77768

RefSeq

NM_001039550 NM_006736

HUGO

OMIM

CCDS

CCDS2439 CCDS46519

HPRD

07249

IMGT

EMBL

GenPept

RNA Seq Atlas