Version 5.4
Bos taurus Gene: PROM1
Summary
InnateDB Gene IDBG-643990.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PROM1
Gene Name prominin-1 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013736
Encoded Proteins
IDBP-696594
prominin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000007062:
This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:115981183-116105180
Strand Reverse strand
Band
Transcripts
ENSBTAT00000018252 ENSBTAP00000018252
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042805 actinin binding
GO:0045296 cadherin binding
Biological Process
GO:0045494 photoreceptor cell maintenance
GO:0060042 retina morphogenesis in camera-type eye
GO:0072112 glomerular visceral epithelial cell differentiation
GO:0072139 glomerular parietal epithelial cell differentiation
GO:2000768 positive regulation of nephron tubule epithelial cell differentiation
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005902 microvillus
GO:0005903 brush border
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0032420 stereocilium
GO:0042622 photoreceptor outer segment membrane
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000007062
View Gene Order
ENSMUSG00000029086
View Gene Order
Cross-References
SwissProt
TrEMBL F1MK52
UniProt Splice Variant
Entrez Gene 618054
UniGene Bt.45160
RefSeq NM_001245952 XM_005208323 XM_005208324 XM_005208325 XM_005208326 XM_005208327 XM_005208328 XM_005208329 XM_005208330 XM_005208331 XM_005208332 XM_005208333 XM_005208335 XM_005208336
HUGO HGNC:9454
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02018745 DAAA02018746 DAAA02018747 DAAA02018748 DAAA02018749 DAAA02018750 DAAA02018751 DAAA02018752 DAAA02018753 DAAA02018754 DAAA02018755 DAAA02018756
GenPept
RNA Seq Atlas 618054

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca