InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Prom1

Summary

InnateDB Gene

IDBG-161637.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prom1

Gene Name

prominin 1

Synonyms

4932416E19Rik; AC133; CD133; Prom; Prom-1; Proml1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029086

Encoded Proteins

IDBP-161639

prominin 1

IDBP-161641

prominin 1

IDBP-161643

prominin 1

IDBP-161645

prominin 1

IDBP-627810

prominin 1

IDBP-627812

prominin 1

IDBP-724820

IDBP-725069

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000007062:
This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:43993625-44102032

Strand

Reverse strand

Band

Transcripts

ENSMUST00000074113	ENSMUSP00000073751
ENSMUST00000087441	ENSMUSP00000084707
ENSMUST00000087442	ENSMUSP00000084709
ENSMUST00000030973	ENSMUSP00000030973
ENSMUST00000171543	ENSMUSP00000128978
ENSMUST00000165909	ENSMUSP00000129909
ENSMUST00000179059	ENSMUSP00000137557
ENSMUST00000177946	ENSMUSP00000136483

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042805	actinin binding
GO:0045296	cadherin binding

Biological Process

GO:0010842	retina layer formation
GO:0045494	photoreceptor cell maintenance
GO:0060042	retina morphogenesis in camera-type eye
GO:0060219	camera-type eye photoreceptor cell differentiation
GO:0072112	glomerular visceral epithelial cell differentiation
GO:0072139	glomerular parietal epithelial cell differentiation
GO:2000768	positive regulation of nephron tubule epithelial cell differentiation

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005902	microvillus
GO:0005903	brush border
GO:0005929	cilium
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031528	microvillus membrane
GO:0032420	stereocilium
GO:0042622	photoreceptor outer segment membrane
GO:0042995	cell projection
GO:0070062	extracellular vesicular exosome
GO:0071914	prominosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000007062

View Gene Order

ENSBTAG00000013736

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.474219 Mm.6250

RefSeq

NM_001163577 NM_001163578 NM_001163581 NM_001163582 NM_001163583 NM_001163584 NM_001163585 NM_008935 XM_006503781 XM_006503782 XM_006503783 XM_006503784 XM_006503785 XM_006503787 XM_006503788 XM_006503789 XM_006503790 XM_006503791

OMIM

CCDS

CCDS39082 CCDS51491 CCDS51492 CCDS51493 CCDS51494 CCDS51495

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas