InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RBBP8

Summary

InnateDB Gene

IDBG-644009.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBBP8

Gene Name

DNA endonuclease RBBP8

Synonyms

CtIP; RBBP-8; RIM; SAE2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006743

Encoded Proteins

IDBP-696620

retinoblastoma-binding protein 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101773:
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 24:33895222-33948196

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000008875

ENSBTAP00000008875

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000014	single-stranded DNA endodeoxyribonuclease activity
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0016787	hydrolase activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000724	double-strand break repair via homologous recombination
GO:0000737	DNA catabolic process, endonucleolytic
GO:0001835	blastocyst hatching
GO:0006281	DNA repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0007126	meiotic nuclear division
GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing
GO:0031572	G2 DNA damage checkpoint
GO:0051301	cell division