InnateDB Protein
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IDBP-696620.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RBBP8
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Protein Name
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retinoblastoma-binding protein 8
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Synonyms
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CtIP; RBBP-8; RIM; SAE2;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000008875
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InnateDB Gene
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IDBG-644009 (RBBP8)
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Protein Structure
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Function |
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Note=Associates with sites of DNA damage in S/G2 phase. Ubiquitinated RBBP8 binds to chromatin following DNA damage (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
40 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019518
Tumour-suppressor protein CtIP N-terminal
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PFAM |
PF10482
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
A6QNQ6
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
512977
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UniGene |
Bt.16288
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RefSeq |
NP_001095436
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC148953
DAAA02056622
DAAA02056623
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GenPept |
AAI48954
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