Version 5.4
Bos taurus Gene: TGIF1
Summary
InnateDB Gene IDBG-644209.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGIF1
Gene Name homeobox protein TGIF1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007718
Encoded Proteins
IDBP-696827
TGFB-induced factor homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177426:
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 24:37940878-37948732
Strand Forward strand
Band
Transcripts
ENSBTAT00000039259 ENSBTAP00000039058
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001843 neural tube closure
GO:0006355 regulation of transcription, DNA-templated
GO:0007368 determination of left/right symmetry
GO:0008285 negative regulation of cell proliferation
GO:0009953 dorsal/ventral pattern formation
GO:0010470 regulation of gastrulation
GO:0038092 nodal signaling pathway
GO:0045666 positive regulation of neuron differentiation
GO:0048146 positive regulation of fibroblast proliferation
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000177426
View Gene Order
ENSMUSG00000047407
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_121111
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
REACT_120734
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
REACT_217958
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_189085
Disease pathway
REACT_215068
Loss of Function of SMAD4 in Cancer pathway
REACT_213336
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_224217
TGFBR1 LBD Mutants in Cancer pathway
REACT_220566
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
REACT_204241
Loss of Function of TGFBR2 in Cancer pathway
REACT_216792
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_224787
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_233572
Gene Expression pathway
REACT_223317
Loss of Function of TGFBR1 in Cancer pathway
REACT_209370
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_202264
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_206529
Generic Transcription Pathway pathway
REACT_188257
Signal Transduction pathway
REACT_224802
TGFBR1 KD Mutants in Cancer pathway
REACT_212101
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_225428
Signaling by TGF-beta Receptor Complex pathway
REACT_226256
Loss of Function of SMAD2/3 in Cancer pathway
KEGG
INOH
PID NCI
ar_pathway
Coregulation of Androgen receptor activity
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL Q3MIB9
UniProt Splice Variant
Entrez Gene 510050
UniGene Bt.49627
RefSeq NM_001128499 XM_005224143 XM_005224144 XM_005224147
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103302 DAAA02056733
GenPept AAI03303
RNA Seq Atlas 510050

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca