Version 5.4
Bos taurus Gene: SIPA1
Summary
InnateDB Gene IDBG-644217.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIPA1
Gene Name signal-induced proliferation-associated protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013884
Encoded Proteins
IDBP-696838
signal-induced proliferation-associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213445:
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:44484284-44493549
Strand Forward strand
Band
Transcripts
ENSBTAT00000018435 ENSBTAP00000018435
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051726 regulation of cell cycle
Cellular Component
Orthologs
Species
Mus musculus
Homo sapiens
Gene ID
Gene Order
ENSMUSG00000056917
View Gene Order
ENSG00000213445
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23898
Rap1 signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
mmu04670
Leukocyte transendothelial migration pathway
hsa04670
Leukocyte transendothelial migration pathway
INOH
PID NCI
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL A6QPH2
UniProt Splice Variant
Entrez Gene 508234
UniGene Bt.21346
RefSeq NM_001101895 XM_005227030
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149322 DAAA02063569
GenPept AAI49323
RNA Seq Atlas 508234

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca