Version 5.4
Mus musculus Gene: Sipa1
Summary
InnateDB Gene IDBG-132413.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sipa1
Gene Name signal-induced proliferation associated gene 1
Synonyms Spa1
Species Mus musculus
Ensembl Gene ENSMUSG00000056917
Encoded Proteins
IDBP-132415
signal-induced proliferation associated gene 1
IDBP-132417
signal-induced proliferation associated gene 1
IDBP-619855
signal-induced proliferation associated gene 1
IDBP-619856
signal-induced proliferation associated gene 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213445:
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:5651185-5663707
Strand Reverse strand
Band A
Transcripts
ENSMUST00000080824 ENSMUSP00000079637
ENSMUST00000071857 ENSMUSP00000073618
ENSMUST00000164304 ENSMUSP00000128208
ENSMUST00000169854 ENSMUSP00000132345
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0042631 cellular response to water deprivation
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051726 regulation of cell cycle
Cellular Component
GO:0030133 transport vesicle
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000213445
View Gene Order
ENSBTAG00000013884
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04670
Leukocyte transendothelial migration pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23898
Rap1 signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04670
Leukocyte transendothelial migration pathway
INOH
PID NCI
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.3072
RefSeq NM_001164480 NM_001164481 NM_001164482 NM_001164568 NM_011379 XM_006531699 XM_006531700
OMIM
CCDS CCDS29474
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca