Version 5.4
Bos taurus Gene: DOHH
Summary
InnateDB Gene IDBG-644423.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOHH
Gene Name Deoxyhypusine hydroxylase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005272
Encoded Proteins
IDBP-697057
Deoxyhypusine hydroxylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129932:
This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:21649441-21654927
Strand Forward strand
Band
Transcripts
ENSBTAT00000006935 ENSBTAP00000006935
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0019135 deoxyhypusine monooxygenase activity
GO:0046872 metal ion binding
Biological Process
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
GO:0055114 oxidation-reduction process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000129932
View Gene Order
ENSMUSG00000078440
View Gene Order
Pathways
NETPATH
REACTOME
REACT_205598
Hypusine synthesis from eIF5A-lysine pathway
REACT_213782
Metabolism of proteins pathway
REACT_214405
Post-translational protein modification pathway
REACT_206715
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12469
Hypusine synthesis from eIF5A-lysine pathway
REACT_22161
Post-translational protein modification pathway
REACT_1069
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_17015
Metabolism of proteins pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_229541
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_203391
Hypusine synthesis from eIF5A-lysine pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.10480
RefSeq NM_001075886 XM_005208948
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca