Version 5.4
Bos taurus Gene: ASPH
Summary
InnateDB Gene IDBG-644533.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASPH
Gene Name Aspartyl/asparaginyl beta-hydroxylase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000026283
Encoded Proteins
IDBP-697177
Aspartyl/asparaginyl beta-hydroxylase
IDBP-697179
Aspartyl/asparaginyl beta-hydroxylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198363:
This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:28700905-28888284
Strand Reverse strand
Band
Transcripts
ENSBTAT00000021267 ENSBTAP00000021267
ENSBTAT00000047216 ENSBTAP00000044438
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004597 peptide-aspartate beta-dioxygenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0007389 pattern specification process
GO:0008285 negative regulation of cell proliferation
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0018193 peptidyl-amino acid modification
GO:0031585 regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0031647 regulation of protein stability
GO:0032237 activation of store-operated calcium channel activity
GO:0033198 response to ATP
GO:0035108 limb morphogenesis
GO:0042264 peptidyl-aspartic acid hydroxylation
GO:0045862 positive regulation of proteolysis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0055114 oxidation-reduction process
GO:0060021 palate development
GO:0060325 face morphogenesis
GO:0070588 calcium ion transmembrane transport
GO:0071277 cellular response to calcium ion
GO:0090316 positive regulation of intracellular protein transport
GO:0097202 activation of cysteine-type endopeptidase activity
GO:1901879 regulation of protein depolymerization
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0032541 cortical endoplasmic reticulum
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000198363
View Gene Order
ENSMUSG00000028207
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q29RR2
UniProt Splice Variant
Entrez Gene 286771
UniGene Bt.46037
RefSeq NM_174757
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114062 DAAA02038406
GenPept AAI14063
RNA Seq Atlas 286771

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca