InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.91151

Summary

InnateDB Gene

IDBG-644544.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.91151

Gene Name

chemokine-binding protein 2

Synonyms

CCBP2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014162

Encoded Proteins

IDBP-697187

chemokine-binding protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21450903

[Homo sapiens] CCBP2 is a marker for innate-like B cells, which are a heterogeneous collection of cells that control infection and suppress inflammation. CCBP2 act as a chemokine scavenger receptor by internalizing chemokines without inducing calcium fluxes or chemotaxis in innate B cells. (Demonstrated in murine model)

PMID 21450903

[Mus musculus] Ccbp2 is a marker for innate-like B cells, which are a heterogeneous collection of cells that control infection and suppress inflammation. Ccbp2 act as a chemokine scavenger receptor by internalizing chemokines without inducing calcium fluxes or chemotaxis in innate B cells.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144648:
This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:15553514-15561007

Strand

Forward strand

Band

Transcripts

ENSBTAT00000052411

ENSBTAP00000047867

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0016493	C-C chemokine receptor activity
GO:0019957	C-C chemokine binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0006935	chemotaxis
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0070098	chemokine-mediated signaling pathway