InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ccbp2

Summary

InnateDB Gene

IDBG-205741.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccbp2

Gene Name

chemokine binding protein 2

Synonyms

AI464239; Ccbp2; CCR10; CCR9; Cmkbr9; D6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000044534

Encoded Proteins

IDBP-205743

chemokine binding protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21450903

Ccbp2 is a marker for innate-like B cells, which are a heterogeneous collection of cells that control infection and suppress inflammation. Ccbp2 act as a chemokine scavenger receptor by internalizing chemokines without inducing calcium fluxes or chemotaxis in innate B cells.

InnateDB Annotation from Orthologs

Summary

PMID 21450903

[Homo sapiens] CCBP2 is a marker for innate-like B cells, which are a heterogeneous collection of cells that control infection and suppress inflammation. CCBP2 act as a chemokine scavenger receptor by internalizing chemokines without inducing calcium fluxes or chemotaxis in innate B cells. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144648:
This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:121898464-121911064

Strand

Forward strand

Band

Transcripts

ENSMUST00000050327

ENSMUSP00000050119

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0016493	C-C chemokine receptor activity
GO:0016494	C-X-C chemokine receptor activity
GO:0019957	C-C chemokine binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0042119	neutrophil activation
GO:0045087	innate immune response (InnateDB)
GO:0070098	chemokine-mediated signaling pathway