Version 5.4
Bos taurus Gene: RBBP4
Summary
InnateDB Gene IDBG-644559.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBBP4
Gene Name Histone-binding protein RBBP4
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005904
Encoded Proteins
IDBP-697204
Histone-binding protein RBBP4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162521:
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:121800923-121817395
Strand Reverse strand
Band
Transcripts
ENSBTAT00000007758 ENSBTAP00000007758
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 138 interaction(s) predicted by orthology.
Predicted by orthology
Total 138 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0005515 protein binding
GO:0008094 DNA-dependent ATPase activity
GO:0031492 nucleosomal DNA binding
GO:0042826 histone deacetylase binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006260 DNA replication
GO:0006335 DNA replication-dependent nucleosome assembly
GO:0006336 DNA replication-independent nucleosome assembly
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007049 cell cycle
GO:0016568 chromatin modification
GO:0031497 chromatin assembly
GO:0043044 ATP-dependent chromatin remodeling
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016581 NuRD complex
GO:0016589 NURF complex
GO:0033186 CAF-1 complex
GO:0035098 ESC/E(Z) complex
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000162521
View Gene Order
ENSMUSG00000057236
View Gene Order
Pathways
NETPATH
REACTOME
REACT_226948
G0 and Early G1 pathway
REACT_213048
Epigenetic regulation of gene expression pathway
REACT_224358
Mitotic G1-G1/S phases pathway
REACT_224944
Nucleosome assembly pathway
REACT_203707
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_217981
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_207088
RNA Polymerase I Transcription pathway
REACT_206069
Cellular responses to stress pathway
REACT_226022
Gene Expression pathway
REACT_207632
Chromatin organization pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_248114
HDACs deacetylate histones pathway
REACT_214934
Cell Cycle pathway
REACT_215025
Cellular Senescence pathway
REACT_225657
Oxidative Stress Induced Senescence pathway
REACT_208197
RNA Polymerase I Transcription Initiation pathway
REACT_227796
Chromosome Maintenance pathway
REACT_207393
PRC2 methylates histones and DNA pathway
REACT_219488
RNA Polymerase I Promoter Clearance pathway
REACT_227044
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22186
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_111214
G0 and Early G1 pathway
REACT_1006
Polo-like kinase mediated events pathway
REACT_953
RNA Polymerase I Transcription Initiation pathway
REACT_120956
Cellular responses to stress pathway
REACT_200808
PRC2 methylates histones and DNA pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_22172
Chromosome Maintenance pathway
REACT_22344
Nucleosome assembly pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_115566
Cell Cycle pathway
REACT_228222
HDACs deacetylate histones pathway
REACT_169274
Cellular Senescence pathway
REACT_172623
Chromatin organization pathway
REACT_2203
G2/M Transition pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_71
Gene Expression pathway
REACT_245058
RNA Polymerase I Transcription pathway
REACT_188970
Oxidative Stress Induced Senescence pathway
REACT_244415
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_200794
Mus musculus biological processes pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_200667
NoRC negatively regulates rRNA expression pathway
REACT_218274
Chromatin organization pathway
REACT_233453
Chromosome Maintenance pathway
REACT_188957
Cellular responses to stress pathway
REACT_199110
G0 and Early G1 pathway
REACT_222475
PRC2 methylates histones and DNA pathway
REACT_188804
Cell Cycle pathway
REACT_214440
NoRC negatively regulates rRNA expression pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_188820
Cellular Senescence pathway
REACT_205737
Epigenetic regulation of gene expression pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_233572
Gene Expression pathway
REACT_207809
Negative epigenetic regulation of rRNA expression pathway
REACT_198595
Nucleosome assembly pathway
REACT_198597
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_257106
HDACs deacetylate histones pathway
REACT_240511
RNA Polymerase I Promoter Clearance pathway
REACT_235780
RNA Polymerase I Transcription Initiation pathway
KEGG
INOH
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
hdac_classi_pathway
Signaling events mediated by HDAC Class I
e2f_pathway
E2F transcription factor network
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt Q3MHL3
TrEMBL
UniProt Splice Variant
Entrez Gene 767940
UniGene Bt.101874 Bt.111752 Bt.69714 Bt.86957
RefSeq NM_001077013 XM_005203010
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105195 BT030530
GenPept AAI05196 ABQ12970
RNA Seq Atlas 767940

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca