InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MKNK2

Summary

InnateDB Gene

IDBG-644643.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MKNK2

Gene Name

MAP kinase-interacting serine/threonine-protein kinase 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018049

Encoded Proteins

IDBP-697295

MAP kinase interacting serine/threonine kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099875:
This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:22787218-22796782

Strand

Forward strand

Band

Transcripts

ENSBTAT00000024029

ENSBTAP00000024029

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0030097	hemopoiesis
GO:0035556	intracellular signal transduction
GO:0071243	cellular response to arsenic-containing substance
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand