Version 5.4
Homo sapiens Gene: MKNK2
Summary
InnateDB Gene IDBG-15316.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MKNK2
Gene Name MAP kinase interacting serine/threonine kinase 2
Synonyms GPRK7; MNK2
Species Homo sapiens
Ensembl Gene ENSG00000099875
Encoded Proteins
IDBP-15318
MAP kinase interacting serine/threonine kinase 2
IDBP-15320
MAP kinase interacting serine/threonine kinase 2
IDBP-760139
IDBP-764013
IDBP-759861
IDBP-766024
IDBP-759816
IDBP-763488
IDBP-763477
IDBP-766197
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:2037465-2051244
Strand Reverse strand
Band p13.3
Transcripts
ENST00000250896 ENSP00000250896
ENST00000309340 ENSP00000309485
ENST00000591601 ENSP00000467811
ENST00000587416
ENST00000588014 ENSP00000465079
ENST00000589534 ENSP00000466064
ENST00000586620
ENST00000591588 ENSP00000464828
ENST00000585667
ENST00000586828 ENSP00000465425
ENST00000591142 ENSP00000465645
ENST00000589441 ENSP00000466594
ENST00000589509 ENSP00000466147
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0046872 metal ion binding
Biological Process
GO:0006417 regulation of translation
GO:0006468 protein phosphorylation
GO:0007166 cell surface receptor signaling pathway
GO:0009103 lipopolysaccharide biosynthetic process
GO:0030097 hemopoiesis
GO:0035556 intracellular signal transduction
GO:0071243 cellular response to arsenic-containing substance
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016605 PML body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020190
View Gene Order
ENSBTAG00000018049
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04910
Insulin signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q9HBH9
TrEMBL A4CYL7 B3KS07 B4DEQ4 K7EIN7
UniProt Splice Variant
Entrez Gene 2872
UniGene Hs.515032 Hs.706934 Hs.707705 Hs.713196
RefSeq NM_017572 NM_199054
HUGO HGNC:7111
OMIM 605069
CCDS CCDS12080 CCDS12079
HPRD 05459
IMGT
EMBL AC007136 AF125532 AF237775 AF237776 AK092536 AK293742 BC073140
GenPept AAD21217 AAF17226 AAG26336 AAG26337 AAH73140 BAG52569 BAG57165
RNA Seq Atlas 2872

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca