Version 5.4
Bos taurus Gene: IL4
Summary
InnateDB Gene IDBG-644671.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL4
Gene Name Interleukin-4
Synonyms BSF-1; IL-4
Species Bos taurus
Ensembl Gene ENSBTAG00000015957
Encoded Proteins
IDBP-697324
Interleukin-4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 7:22993179-23001067
Strand Reverse strand
Band
Transcripts
ENSBTAT00000021215 ENSBTAP00000021215
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005136 interleukin-4 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002227 innate immune response in mucosa
GO:0002296 T-helper 1 cell lineage commitment
GO:0006955 immune response
GO:0008203 cholesterol metabolic process
GO:0030890 positive regulation of B cell proliferation
GO:0031296 B cell costimulation
GO:0032736 positive regulation of interleukin-13 production
GO:0035745 T-helper 2 cell cytokine production
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042113 B cell activation
GO:0042325 regulation of phosphorylation
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042832 defense response to protozoan
GO:0043066 negative regulation of apoptotic process
GO:0045064 T-helper 2 cell differentiation
GO:0045080 positive regulation of chemokine biosynthetic process
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045582 positive regulation of T cell differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048295 positive regulation of isotype switching to IgE isotypes
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776 regulation of immune response
GO:0050868 negative regulation of T cell activation
GO:0050871 positive regulation of B cell activation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0097028 dendritic cell differentiation
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2000320 negative regulation of T-helper 17 cell differentiation
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.423
RefSeq NM_173921
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca