InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: IL4

Summary

InnateDB Protein

IDBP-697324.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL4

Protein Name

Interleukin-4

Synonyms

BSF-1; IL-4;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000021215

InnateDB Gene

IDBG-644671 (IL4)

Protein Structure

UniProt Annotation

Function

Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005136	interleukin-4 receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0002227	innate immune response in mucosa
GO:0002296	T-helper 1 cell lineage commitment
GO:0006955	immune response
GO:0008203	cholesterol metabolic process
GO:0030890	positive regulation of B cell proliferation
GO:0031296	B cell costimulation
GO:0032736	positive regulation of interleukin-13 production
GO:0035745	T-helper 2 cell cytokine production
GO:0042102	positive regulation of T cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0042113	B cell activation
GO:0042325	regulation of phosphorylation
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042832	defense response to protozoan
GO:0043066	negative regulation of apoptotic process
GO:0045064	T-helper 2 cell differentiation
GO:0045080	positive regulation of chemokine biosynthetic process
GO:0045348	positive regulation of MHC class II biosynthetic process
GO:0045582	positive regulation of T cell differentiation
GO:0045671	negative regulation of osteoclast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048295	positive regulation of isotype switching to IgE isotypes
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776	regulation of immune response
GO:0050868	negative regulation of T cell activation
GO:0050871	positive regulation of B cell activation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0097028	dendritic cell differentiation
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2000320	negative regulation of T-helper 17 cell differentiation
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0009897	external side of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001325 Interleukin-4/interleukin-13
IPR002354 Interleukin-4
IPR009079 Four-helical cytokine-like, core

PFAM

PF00727

PRINTS

PR00431

PIRSF

PIRSF001941

SMART

SM00190

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P30367

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

280824

UniGene

Bt.423

RefSeq

NP_776346

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

EU276069 M77120 U14131 U14159 U14160

GenPept

AAA30587 AAA82730 ABX72067