InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SLC22A5

Summary

InnateDB Gene

IDBG-644682.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC22A5

Gene Name

solute carrier family 22 member 5

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000668

Encoded Proteins

IDBP-697334

solute carrier family 22 member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197375:
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:23329260-23355525

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000035731

ENSBTAP00000035601

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0015075	ion transmembrane transporter activity
GO:0015226	carnitine transmembrane transporter activity
GO:0015651	quaternary ammonium group transmembrane transporter activity
GO:0022857	transmembrane transporter activity
GO:0030165	PDZ domain binding

Biological Process

GO:0006810	transport
GO:0015697	quaternary ammonium group transport
GO:0015879	carnitine transport
GO:0034220	ion transmembrane transport
GO:0052106	quorum sensing involved in interaction with host
GO:0055085	transmembrane transport
GO:0060731	positive regulation of intestinal epithelial structure maintenance
GO:0070715	sodium-dependent organic cation transport
GO:1902603	carnitine transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane
GO:0070062	extracellular vesicular exosome