InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TADA3

Summary

InnateDB Gene

IDBG-644713.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TADA3

Gene Name

Transcriptional adapter 3

Synonyms

TADA3L

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007961

Encoded Proteins

IDBP-697373

Transcriptional adapter 3

IDBP-697374

Transcriptional adapter 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171148:
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:16966879-16978442

Strand

Forward strand

Band

Transcripts

ENSBTAT00000047754	ENSBTAP00000044929
ENSBTAT00000010467	ENSBTAP00000010467

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0019904	protein domain specific binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007067	mitotic nuclear division
GO:0010628	positive regulation of gene expression
GO:0031063	regulation of histone deacetylation
GO:0031647	regulation of protein stability
GO:0043966	histone H3 acetylation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0090043	regulation of tubulin deacetylation

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
GO:0030914	STAGA complex
GO:0033276	transcription factor TFTC complex
GO:0072686	mitotic spindle