Version 5.4
Mus musculus Gene: Tada3
Summary
InnateDB Gene IDBG-176433.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tada3
Gene Name transcriptional adaptor 3
Synonyms 1110004B19Rik; ADA3; AI987856; Tada3l
Species Mus musculus
Ensembl Gene ENSMUSG00000048930
Encoded Proteins
IDBP-165353
transcriptional adaptor 3
IDBP-176435
transcriptional adaptor 3
IDBP-254578
transcriptional adaptor 3
IDBP-254580
transcriptional adaptor 3
IDBP-254582
transcriptional adaptor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171148:
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:113366025-113377883
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000043333 ENSMUSP00000043363
ENSMUST00000032410 ENSMUSP00000032410
ENSMUST00000099118 ENSMUSP00000108736
ENSMUST00000113107 ENSMUSP00000108731
ENSMUST00000113106 ENSMUSP00000108730
ENSMUST00000125414
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0019904 protein domain specific binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0006351 transcription, DNA-templated
GO:0007067 mitotic nuclear division
GO:0010628 positive regulation of gene expression
GO:0031063 regulation of histone deacetylation
GO:0031647 regulation of protein stability
GO:0043966 histone H3 acetylation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0090043 regulation of tubulin deacetylation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex
GO:0030914 STAGA complex
GO:0033276 transcription factor TFTC complex
GO:0072686 mitotic spindle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171148
View Gene Order
ENSBTAG00000007961
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_226917
HATs acetylate histones pathway
REACT_202766
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_207632
Chromatin organization pathway
REACT_219482
HATs acetylate histones pathway
REACT_227044
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.266811
RefSeq NM_133932
OMIM
CCDS CCDS20416
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca