InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.23286

Summary

InnateDB Gene

IDBG-644763.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.23286

Gene Name

telomeric repeat-binding factor 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000032982

Encoded Proteins

IDBP-697425

telomeric repeat-binding factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147601:
This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:38500940-38543991

Strand

Forward strand

Band

Transcripts

ENSBTAT00000046824

ENSBTAP00000044076

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 265 interaction(s) predicted by orthology.

Predicted by orthology
Total	265 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003691	double-stranded telomeric DNA binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008301	DNA binding, bending
GO:0042162	telomeric DNA binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000723	telomere maintenance
GO:0001309	age-dependent telomere shortening
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007094	mitotic spindle assembly checkpoint
GO:0008156	negative regulation of DNA replication
GO:0010834	telomere maintenance via telomere shortening
GO:0031116	positive regulation of microtubule polymerization
GO:0032211	negative regulation of telomere maintenance via telomerase
GO:0043065	positive regulation of apoptotic process
GO:0045840	positive regulation of mitosis
GO:0045931	positive regulation of mitotic cell cycle
GO:0051260	protein homooligomerization
GO:0051974	negative regulation of telomerase activity

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000783	nuclear telomere cap complex
GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005730	nucleolus