InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Terf1

Summary

InnateDB Gene

IDBG-134893.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Terf1

Gene Name

telomeric repeat binding factor 1

Synonyms

Pin2; Trbf1; Trf1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025925

Encoded Proteins

IDBP-134895

telomeric repeat binding factor 1

IDBP-788997

telomeric repeat binding factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that binds to repeats in telomeres to form a nucleoprotein complex that protects against the degradation of chromosomal ends. The encoded protein regulates the length of telomeres and is an integral structural component of the functional telomere. This protein is thought to play a role in spindle formation in mitosis. Mutations in this gene are associated with bone marrow failure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:15805646-15844052

Strand

Forward strand

Band

Transcripts

ENSMUST00000027057	ENSMUSP00000027057
ENSMUST00000188371	ENSMUSP00000140744
ENSMUST00000186565
ENSMUST00000188684

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 276 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	5 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	276 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003691	double-stranded telomeric DNA binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008301	DNA binding, bending
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010521	telomerase inhibitor activity
GO:0042162	telomeric DNA binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000723	telomere maintenance
GO:0001309	age-dependent telomere shortening
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007067	mitotic nuclear division
GO:0007094	mitotic spindle assembly checkpoint
GO:0008156	negative regulation of DNA replication
GO:0010834	telomere maintenance via telomere shortening
GO:0031116	positive regulation of microtubule polymerization
GO:0032211	negative regulation of telomere maintenance via telomerase
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0045840	positive regulation of mitosis
GO:0045931	positive regulation of mitotic cell cycle
GO:0051260	protein homooligomerization
GO:0051974	negative regulation of telomerase activity
GO:1900119	positive regulation of execution phase of apoptosis

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000783	nuclear telomere cap complex
GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005819	spindle