InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.91190

Summary

InnateDB Gene

IDBG-644769.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.91190

Gene Name

transcription factor 4

Synonyms

TCF7L2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016462

Encoded Proteins

IDBP-697437

transcription factor 7-like 2

IDBP-697438

transcription factor 7-like 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18854153

[Homo sapiens] Transcription Factor that is an essential and specific regulator of Plasmacytoid dendritic cell development

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196628:
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Aug 2011]
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box (\'E-box\') binding site (\'CANNTG\') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 24:55056433-55435276

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000031010	ENSBTAP00000030974
ENSBTAT00000031006	ENSBTAP00000030970

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.

Predicted by orthology
Total	86 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001011	sequence-specific DNA binding RNA polymerase recruiting transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001087	TFIIB-class binding transcription factor activity
GO:0001093	TFIIB-class transcription factor binding
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0045666	positive regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0065004	protein-DNA complex assembly