Version 5.4
Bos taurus Gene: ATP8B1
Summary
InnateDB Gene IDBG-644820.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP8B1
Gene Name probable phospholipid-transporting ATPase IC
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005738
Encoded Proteins
IDBP-697490
ATPase, aminophospholipid transporter, class I, type 8B, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000081923:
This gene encodes a member of the P-type cation transport ATPase family, which belongs to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Mutations in this gene may result in progressive familial intrahepatic cholestasis type 1 and in benign recurrent intrahepatic cholestasis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 24:57380076-57487773
Strand Reverse strand
Band
Transcripts
ENSBTAT00000007542 ENSBTAP00000007542
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004012 phospholipid-translocating ATPase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0019829 cation-transporting ATPase activity
GO:0046872 metal ion binding
GO:1901612 cardiolipin binding
Biological Process
GO:0006812 cation transport
GO:0006855 drug transmembrane transport
GO:0007605 sensory perception of sound
GO:0008206 bile acid metabolic process
GO:0015914 phospholipid transport
GO:0021650 vestibulocochlear nerve formation
GO:0032534 regulation of microvillus assembly
GO:0045332 phospholipid translocation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0060119 inner ear receptor cell development
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0032420 stereocilium
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000081923
View Gene Order
ENSMUSG00000039529
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25149
Ion transport by P-type ATPases pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_250224
Ion transport by P-type ATPases pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BPC3
UniProt Splice Variant
Entrez Gene 541187
UniGene Bt.112028
RefSeq NM_001192839
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02057153 DAAA02057154
GenPept
RNA Seq Atlas 541187

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca