Version 5.4
Bos taurus Gene: CRBN
Summary
InnateDB Gene IDBG-644836.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRBN
Gene Name Protein cereblon
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019536
Encoded Proteins
IDBP-697505
Protein cereblon
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113851:
This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:23229272-23251050
Strand Forward strand
Band
Transcripts
ENSBTAT00000026031 ENSBTAP00000026031
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004176 ATP-dependent peptidase activity
GO:0005515 protein binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006508 proteolysis
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000113851
View Gene Order
ENSMUSG00000005362
View Gene Order
Cross-References
SwissProt Q0P564
TrEMBL
UniProt Splice Variant
Entrez Gene 511585
UniGene Bt.91518 Bt.95525
RefSeq NM_001075527 XM_005222643 XM_005222644 XM_005222645 XM_005222646
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120452
GenPept AAI20453
RNA Seq Atlas 511585

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca