InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Crbn

Summary

InnateDB Gene

IDBG-174064.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crbn

Gene Name

cereblon

Synonyms

2610203G15Rik; 2900045O07Rik; AF229032; AW108261; piL

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005362

Encoded Proteins

IDBP-174066

cereblon

IDBP-174068

cereblon

IDBP-254295

cereblon

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein with a Lon protease domain, a "regulators of G protein-signaling" (RGS)-like domain and a leucine zipper. It has been proposed to regulate the assembly and surface expression of large-conductance calcium-activated potassium channels in brain and to bind thalidomide. In humans mutation in this gene causes autosomal recessive nonsyndromic mental retardation. In mouse deficiency of this gene serves as a model to study the molecular mechanisms governing learning and memory as they relate to intellectual disability. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
This gene encodes a protein with a Lon protease domain, a "regulators of G protein-signaling" (RGS)-like domain and a leucine zipper. It has been proposed to regulate the assembly and surface expression of large-conductance calcium-activated potassium channels in brain and to bind thalidomide. In humans mutation in this gene causes autosomal recessive nonsyndromic mental retardation. In mouse deficiency of this gene serves as a model to study the molecular mechanisms governing learning and memory as they relate to intellectual disability. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:106778249-106800074

Strand

Reverse strand

Band

Transcripts

ENSMUST00000049675	ENSMUSP00000061604
ENSMUST00000013882	ENSMUSP00000013882
ENSMUST00000113239	ENSMUSP00000108865
ENSMUST00000151484
ENSMUST00000147087

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004176	ATP-dependent peptidase activity
GO:0005515	protein binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006508	proteolysis
GO:0016567	protein ubiquitination
GO:0032463	negative regulation of protein homooligomerization
GO:0034766	negative regulation of ion transmembrane transport
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0090073	positive regulation of protein homodimerization activity

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000113851

View Gene Order

ENSBTAG00000019536

Not yet available

Cross-References

SwissProt

Q8C7D2

TrEMBL

UniProt Splice Variant

Entrez Gene

58799

UniGene

Mm.290085

RefSeq

NM_175357 NM_021449

OMIM

CCDS

CCDS39583 CCDS39584

HPRD

IMGT

MGI ID

MGI:1913277

MGI Symbol

Crbn

EMBL

AF229032 AK050557 AK076144 AK077707 AK160219 BC046967 BC069905 BC086488

GenPept

AAF35895 AAH46967 AAH69905 AAH86488 BAC34322 BAC36214 BAC36970 BAE35697

RNA Seq Atlas

58799