Version 5.4
Bos taurus Gene: PAG1
Summary
InnateDB Gene IDBG-644850.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAG1
Gene Name Pregnancy-associated glycoprotein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014026
Encoded Proteins
IDBP-697517
phosphoprotein associated with glycosphingolipid microdomains 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076641:
The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:46336282-46354162
Strand Reverse strand
Band
Transcripts
ENSBTAT00000018628 ENSBTAP00000018628
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042169 SH2 domain binding
Biological Process
GO:0035556 intracellular signal transduction
GO:0050863 regulation of T cell activation
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0005886 plasma membrane
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000076641
View Gene Order
ENSMUSG00000027508
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_12582
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_12526
TCR signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_116125
Disease pathway
REACT_189085
Disease pathway
REACT_216080
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_230745
Immune System pathway
REACT_242976
Signaling by EGFR pathway
REACT_229531
Adaptive Immune System pathway
REACT_206286
GAB1 signalosome pathway
REACT_188257
Signal Transduction pathway
REACT_222648
TCR signaling pathway
REACT_188180
Signaling by EGFR in Cancer pathway
KEGG
INOH
PID NCI
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
cxcr4_pathway
CXCR4-mediated signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
bcr_5pathway
BCR signaling pathway
shp2_pathway
SHP2 signaling
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL F1MQC1
UniProt Splice Variant
Entrez Gene 614460
UniGene
RefSeq XM_002692713 XM_005194520 XM_005215558 XM_865981
HUGO HGNC:30043
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02039015
GenPept
RNA Seq Atlas 614460

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca