Version 5.4
Homo sapiens Gene: PAG1
Summary
InnateDB Gene IDBG-26542.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAG1
Gene Name phosphoprotein associated with glycosphingolipid microdomains 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000076641
Encoded Proteins
IDBP-26544
phosphoprotein associated with glycosphingolipid microdomains 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:80967810-81112068
Strand Reverse strand
Band q21.13
Transcripts
ENST00000220597 ENSP00000220597
ENST00000523463
ENST00000522811
ENST00000519326
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0042169 SH2 domain binding
Biological Process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0035556 intracellular signal transduction
GO:0050852 T cell receptor signaling pathway
GO:0050863 regulation of T cell activation
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027508
View Gene Order
ENSBTAG00000014026
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_12582
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_12526
TCR signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
cxcr4_pathway
CXCR4-mediated signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
bcr_5pathway
BCR signaling pathway
shp2_pathway
SHP2 signaling
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.266175 Hs.673010
RefSeq NM_018440 XM_006716461 XM_006716462
HUGO
OMIM
CCDS CCDS6227
HPRD 16944
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca