InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SLC12A2

Summary

InnateDB Gene

IDBG-644856.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC12A2

Gene Name

solute carrier family 12 member 2

Synonyms

bsc2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009637

Encoded Proteins

IDBP-697537

solute carrier family 12 member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000064651:
The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:26973462-27064924

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000012701

ENSBTAP00000012701

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0008519	ammonium transmembrane transporter activity
GO:0015377	cation:chloride symporter activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0015696	ammonium transport
GO:0030321	transepithelial chloride transport
GO:0035264	multicellular organism growth
GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
GO:0055085	transmembrane transport
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0060763	mammary duct terminal end bud growth
GO:0070634	transepithelial ammonium transport
GO:0072488	ammonium transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome