InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.22086

Summary

InnateDB Gene

IDBG-644916.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.22086

Gene Name

alpha-aminoadipic semialdehyde dehydrogenase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009646

Encoded Proteins

IDBP-697586

alpha-aminoadipic semialdehyde dehydrogenase

IDBP-697588

alpha-aminoadipic semialdehyde dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164904:
The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:28572141-28617279

Strand

Forward strand

Band

Transcripts

ENSBTAT00000055519	ENSBTAP00000048297
ENSBTAT00000012710	ENSBTAP00000012710

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor