InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aldh7a1

Summary

InnateDB Gene

IDBG-147695.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aldh7a1

Gene Name

aldehyde dehydrogenase family 7, member A1

Synonyms

Atq1; D18Wsu181e

Species

Mus musculus

Ensembl Gene

ENSMUSG00000053644

Encoded Proteins

IDBP-147697

aldehyde dehydrogenase family 7, member A1

IDBP-622782

aldehyde dehydrogenase family 7, member A1

IDBP-622783

aldehyde dehydrogenase family 7, member A1

IDBP-622785

aldehyde dehydrogenase family 7, member A1

IDBP-622787

aldehyde dehydrogenase family 7, member A1

IDBP-622789

aldehyde dehydrogenase family 7, member A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164904:
The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:56509687-56572951

Strand

Reverse strand

Band

Transcripts

ENSMUST00000066208	ENSMUSP00000065089
ENSMUST00000172902
ENSMUST00000174518	ENSMUSP00000133372
ENSMUST00000172734	ENSMUSP00000134192
ENSMUST00000174704	ENSMUSP00000133970
ENSMUST00000168517
ENSMUST00000170309	ENSMUSP00000127625
ENSMUST00000171851
ENSMUST00000171844	ENSMUSP00000127652

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity
GO:0005515	protein binding
GO:0008802	betaine-aldehyde dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor