Version 5.4
Bos taurus Gene: PIGN
Summary
InnateDB Gene IDBG-644942.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIGN
Gene Name GPI ethanolamine phosphate transferase 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000016663
Encoded Proteins
IDBP-697613
phosphatidylinositol glycan anchor biosynthesis, class N
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197563:
This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is expressed in the endoplasmic reticulum and transfers phosphoethanolamine (EtNP) to the first mannose of the GPI anchor. Two alternatively spliced variants, which encode an identical isoform, have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 24:60978529-61087325
Strand Reverse strand
Band
Transcripts
ENSBTAT00000022160 ENSBTAP00000022160
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0016740 transferase activity
Biological Process
GO:0006506 GPI anchor biosynthetic process
GO:0008152 metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000197563
View Gene Order
ENSMUSG00000056536
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_952
Synthesis of glycosylphosphatidylinositol (GPI) pathway
REACT_1853
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
mmu00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BM45
UniProt Splice Variant
Entrez Gene 525095
UniGene Bt.10261
RefSeq NM_001192606 XM_005224182 XM_005224183
HUGO HGNC:8967
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02057221 DAAA02057222
GenPept
RNA Seq Atlas 525095

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca