Version 5.4
Bos taurus Gene: DPYS
Summary
InnateDB Gene IDBG-644965.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPYS
Gene Name dihydropyrimidinase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021887
Encoded Proteins
IDBP-697641
dihydropyrimidinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147647:
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:62328132-62418497
Strand Forward strand
Band
Transcripts
ENSBTAT00000029176 ENSBTAP00000029176
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004157 dihydropyrimidinase activity
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0051219 phosphoprotein binding
Biological Process
GO:0006208 pyrimidine nucleobase catabolic process
GO:0006212 uracil catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000147647
View Gene Order
ENSMUSG00000022304
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1023
Pyrimidine catabolism pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_957
Pyrimidine metabolism pathway
REACT_111217
Metabolism pathway
REACT_236186
Pyrimidine metabolism pathway
REACT_188937
Metabolism pathway
REACT_241108
Pyrimidine catabolism pathway
REACT_245662
Metabolism of nucleotides pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00770
Pantothenate and CoA biosynthesis pathway
hsa00410
beta-Alanine metabolism pathway
hsa00983
Drug metabolism pathway
mmu00410
beta-Alanine metabolism pathway
mmu00240
Pyrimidine metabolism pathway
mmu00770
Pantothenate and CoA biosynthesis pathway
mmu00983
Drug metabolism pathway
INOH
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL E1BFN6
UniProt Splice Variant
Entrez Gene 509241
UniGene Bt.105702 Bt.50049
RefSeq NM_001192214 XM_005215565
HUGO HGNC:3013
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02039299 DAAA02039300
GenPept
RNA Seq Atlas 509241

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca