Version 5.4
Homo sapiens Gene: DPYS
Summary
InnateDB Gene IDBG-32048.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPYS
Gene Name dihydropyrimidinase
Synonyms DHP; DHPase
Species Homo sapiens
Ensembl Gene ENSG00000147647
Encoded Proteins
IDBP-32050
dihydropyrimidinase
IDBP-480267
dihydropyrimidinase
IDBP-599190
dihydropyrimidinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:104330324-104467053
Strand Reverse strand
Band q22.3
Transcripts
ENST00000351513 ENSP00000276651
ENST00000520806
ENST00000520483
ENST00000521372
ENST00000519217
ENST00000521573 ENSP00000430246
ENST00000533874 ENSP00000436654
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002058 uracil binding
GO:0002059 thymine binding
GO:0004157 dihydropyrimidinase activity
GO:0008270 zinc ion binding
GO:0016597 amino acid binding
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0051219 phosphoprotein binding
Biological Process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006208 pyrimidine nucleobase catabolic process
GO:0006210 thymine catabolic process
GO:0006212 uracil catabolic process
GO:0008152 metabolic process
GO:0019482 beta-alanine metabolic process
GO:0019860 uracil metabolic process
GO:0044281 small molecule metabolic process
GO:0046135 pyrimidine nucleoside catabolic process
GO:0051260 protein homooligomerization
GO:0051289 protein homotetramerization
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022304
View Gene Order
ENSBTAG00000021887
Not yet available
Pathways
NETPATH
REACTOME
REACT_1023
Pyrimidine catabolism pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_957
Pyrimidine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00770
Pantothenate and CoA biosynthesis pathway
hsa00410
beta-Alanine metabolism pathway
hsa00983
Drug metabolism pathway
INOH
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt Q14117
TrEMBL E5RG28
UniProt Splice Variant
Entrez Gene 1807
UniGene Hs.443161 Hs.628120 Hs.713087
RefSeq NM_001385 XM_005250819
HUGO HGNC:3013
OMIM 613326
CCDS CCDS6302
HPRD
IMGT
EMBL AB004678 AP002847 AP003471 BC034395 D78011
GenPept AAH34395 BAA11189 BAA33067
RNA Seq Atlas 1807

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca