InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: UBA3

Summary

InnateDB Gene

IDBG-645021.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBA3

Gene Name

NEDD8-activating enzyme E1 catalytic subunit

Synonyms

UBE1C

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015556

Encoded Proteins

IDBP-697708

NEDD8-activating enzyme E1 catalytic subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144744:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:32583221-32607984

Strand

Forward strand

Band

Transcripts

ENSBTAT00000020672

ENSBTAP00000020672

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008641	small protein activating enzyme activity
GO:0016881	acid-amino acid ligase activity
GO:0019781	NEDD8 activating enzyme activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0006464	cellular protein modification process
GO:0007113	endomitotic cell cycle
GO:0045116	protein neddylation
GO:0051726	regulation of cell cycle