InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBA3

Summary

InnateDB Gene

IDBG-43924.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBA3

Gene Name

ubiquitin-like modifier activating enzyme 3

Synonyms

hUBA3; NAE2; UBE1C

Species

Homo sapiens

Ensembl Gene

ENSG00000144744

Encoded Proteins

IDBP-43926

ubiquitin-like modifier activating enzyme 3

IDBP-43928

ubiquitin-like modifier activating enzyme 3

IDBP-381129

ubiquitin-like modifier activating enzyme 3

IDBP-475202

ubiquitin-like modifier activating enzyme 3

IDBP-477922

ubiquitin-like modifier activating enzyme 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:69054730-69080408

Strand

Reverse strand

Band

p14.1

Transcripts

ENST00000361055	ENSP00000354340
ENST00000349511	ENSP00000340041
ENST00000415609	ENSP00000400294
ENST00000461934	ENSP00000417547
ENST00000465627	ENSP00000419077
ENST00000461522
ENST00000465108
ENST00000493957
ENST00000466763
ENST00000485424
ENST00000464605

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008641	small protein activating enzyme activity
GO:0016881	acid-amino acid ligase activity
GO:0019781	NEDD8 activating enzyme activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0006464	cellular protein modification process
GO:0006508	proteolysis
GO:0007113	endomitotic cell cycle
GO:0008152	metabolic process
GO:0045116	protein neddylation
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030061

View Gene Order

ENSBTAG00000015556

Not yet available

Pathways

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

erb_genomic_pathway

Validated nuclear estrogen receptor beta network

era_genomic_pathway

Validated nuclear estrogen receptor alpha network

ar_pathway

Coregulation of Androgen receptor activity

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.154320 Hs.625115

RefSeq

NM_003968 NM_198195

HUGO

OMIM

CCDS

CCDS2909 CCDS2910

HPRD

04413

IMGT

EMBL

GenPept

RNA Seq Atlas