Version 5.4
Bos taurus Gene: AZIN1
Summary
InnateDB Gene IDBG-645037.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AZIN1
Gene Name antizyme inhibitor 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007943
Encoded Proteins
IDBP-697719
antizyme inhibitor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:63767802-63802407
Strand Forward strand
Band
Transcripts
ENSBTAT00000010441 ENSBTAP00000010441
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0042978 ornithine decarboxylase activator activity
Biological Process
GO:0006596 polyamine biosynthetic process
GO:0042177 negative regulation of protein catabolic process
GO:0043085 positive regulation of catalytic activity
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000155096
View Gene Order
ENSMUSG00000037458
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13565
Regulation of ornithine decarboxylase (ODC) pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_234963
Regulation of ornithine decarboxylase (ODC) pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A3KMV9
UniProt Splice Variant
Entrez Gene 532835
UniGene Bt.101763 Bt.26471
RefSeq NM_001082611
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133309 DAAA02039327 DAAA02039328 DAAA02039329
GenPept AAI33310
RNA Seq Atlas 532835

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca