Version 5.4
Homo sapiens Gene: AZIN1
Summary
InnateDB Gene IDBG-31427.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AZIN1
Gene Name antizyme inhibitor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000155096
Encoded Proteins
IDBP-31429
antizyme inhibitor 1
IDBP-31431
antizyme inhibitor 1
IDBP-810322
antizyme inhibitor 1
IDBP-480555
antizyme inhibitor 1
IDBP-483576
antizyme inhibitor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:102826357-102893864
Strand Reverse strand
Band q22.3
Transcripts
ENST00000337198 ENSP00000337180
ENST00000347770 ENSP00000321507
ENST00000518697
ENST00000523071
ENST00000521536 ENSP00000475919
ENST00000522311
ENST00000520402 ENSP00000429449
ENST00000518353 ENSP00000429215
ENST00000518940
ENST00000517581
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 7 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004857 enzyme inhibitor activity
GO:0042978 ornithine decarboxylase activator activity
Biological Process
GO:0006521 regulation of cellular amino acid metabolic process
GO:0006596 polyamine biosynthetic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0042177 negative regulation of protein catabolic process
GO:0043085 positive regulation of catalytic activity
GO:0043086 negative regulation of catalytic activity
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037458
View Gene Order
ENSBTAG00000007943
Not yet available
Pathways
NETPATH
REACTOME
REACT_13565
Regulation of ornithine decarboxylase (ODC) pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.713994
RefSeq NM_015878 NM_148174 XM_005250969
HUGO
OMIM
CCDS CCDS6295
HPRD 07443
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca