Version 5.4
Bos taurus Gene: CLTB
Summary
InnateDB Gene IDBG-645068.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLTB
Gene Name Clathrin light chain B
Synonyms CLTLB
Species Bos taurus
Ensembl Gene ENSBTAG00000010740
Encoded Proteins
IDBP-697774
Clathrin light chain B
IDBP-697776
Clathrin light chain B
IDBP-697777
Clathrin light chain B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175416:
Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:39210710-39230761
Strand Reverse strand
Band
Transcripts
ENSBTAT00000064630 ENSBTAP00000055957
ENSBTAT00000014220 ENSBTAP00000014220
ENSBTAT00000014218 ENSBTAP00000014218
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0016020 membrane
GO:0030118 clathrin coat
GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0030132 clathrin coat of coated pit
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0060170 ciliary membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000175416
View Gene Order
ENSMUSG00000047547
View Gene Order
Pathways
NETPATH
REACTOME
REACT_212636
Signaling by Wnt pathway
REACT_217562
WNT5A-dependent internalization of FZD4 pathway
REACT_203998
Gap junction trafficking pathway
REACT_214353
Signal Transduction pathway
REACT_202965
Formation of annular gap junctions pathway
REACT_206800
beta-catenin independent WNT signaling pathway
REACT_224535
Gap junction trafficking and regulation pathway
REACT_207926
PCP/CE pathway pathway
REACT_207353
Gap junction degradation pathway
REACT_213260
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11049
Formation of annular gap junctions pathway
REACT_11035
Gap junction degradation pathway
REACT_172581
PCP/CE pathway pathway
REACT_111045
Developmental Biology pathway
REACT_172599
WNT5A-dependent internalization of FZD4 pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_9411
Gap junction trafficking pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_11123
Membrane Trafficking pathway
REACT_224389
Gap junction trafficking and regulation pathway
REACT_222404
WNT5A-dependent internalization of FZD4 pathway
REACT_214014
Signaling by Wnt pathway
REACT_209837
Membrane Trafficking pathway
REACT_220352
Formation of annular gap junctions pathway
REACT_226355
beta-catenin independent WNT signaling pathway
REACT_214043
PCP/CE pathway pathway
REACT_209040
Gap junction degradation pathway
REACT_217189
Gap junction trafficking pathway
REACT_188257
Signal Transduction pathway
KEGG
hsa04142
Lysosome pathway
hsa04144
Endocytosis pathway
hsa05016
Huntington's disease pathway
hsa05100
Bacterial invasion of epithelial cells pathway
mmu04142
Lysosome pathway
mmu05016
Huntington's disease pathway
mmu04144
Endocytosis pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
arf_3pathway
Arf1 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_174277 XM_005209121
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca