Version 5.4
Homo sapiens Gene: CLTB
Summary
InnateDB Gene IDBG-58860.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLTB
Gene Name clathrin, light chain B
Synonyms LCB
Species Homo sapiens
Ensembl Gene ENSG00000175416
Encoded Proteins
IDBP-58862
clathrin, light chain B
IDBP-58864
clathrin, light chain B
IDBP-484670
clathrin, light chain B
IDBP-480152
clathrin, light chain B
IDBP-482482
clathrin, light chain B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:176392455-176416569
Strand Reverse strand
Band q35.2
Transcripts
ENST00000310418 ENSP00000309415
ENST00000345807 ENSP00000310812
ENST00000508425 ENSP00000424739
ENST00000510734 ENSP00000422978
ENST00000502877 ENSP00000427229
ENST00000507821
ENST00000509319
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0042277 peptide binding
Biological Process
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0030118 clathrin coat
GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0030132 clathrin coat of coated pit
GO:0060170 ciliary membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000047547
View Gene Order
ENSBTAG00000010740
Not yet available
Pathways
NETPATH
REACTOME
REACT_11049
Formation of annular gap junctions pathway
REACT_11035
Gap junction degradation pathway
REACT_172581
PCP/CE pathway pathway
REACT_111045
Developmental Biology pathway
REACT_172599
WNT5A-dependent internalization of FZD4 pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_9411
Gap junction trafficking pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04142
Lysosome pathway
hsa04144
Endocytosis pathway
hsa05016
Huntington's disease pathway
hsa05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
arf_3pathway
Arf1 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.484241 Hs.738395
RefSeq NM_001834 NM_007097
HUGO
OMIM
CCDS CCDS4402 CCDS4403
HPRD 00352
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca