Version 5.4
| Bos taurus Gene: F2RL2 | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-645157.3 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | F2RL2 | ||||||||||
| Gene Name | proteinase-activated receptor 3 precursor | ||||||||||
| Synonyms | |||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Gene | ENSBTAG00000000898 | ||||||||||
| Encoded Proteins |
proteinase-activated receptor 3 precursor
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| Protein Structure | |||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| InnateDB Annotation from Orthologs | |||||||||||
| Summary |
[Homo sapiens] F2RL2 is able to signal autonomously to induce IL8 release mediated by ERK1/2 phosphorylation, which contributes actively to inflammatory responses.
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| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164220:
This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 10:7777600-7788321 | ||||||||||
| Strand | Reverse strand | ||||||||||
| Band | |||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Thrombin signalling through proteinase activated receptors (PARs) pathway
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Hemostasis pathway
GPCR downstream signaling pathway
Hemostasis pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Platelet activation, signaling and aggregation pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
Thrombin signalling through proteinase activated receptors (PARs) pathway
G alpha (q) signalling events pathway
Signal Transduction pathway
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| KEGG |
Neuroactive ligand-receptor interaction pathway
Neuroactive ligand-receptor interaction pathway
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| INOH | |||||||||||
| PID NCI |
Nephrin/Neph1 signaling in the kidney podocyte
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
PAR1-mediated thrombin signaling events
ErbB1 downstream signaling
CDC42 signaling events
PAR4-mediated thrombin signaling events
RhoA signaling pathway
Insulin Pathway
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| Cross-References | |||||||||||
| SwissProt | |||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | |||||||||||
| UniGene | Bt.103924 Bt.24447 | ||||||||||
| RefSeq | NM_001038533 | ||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | |||||||||||
| GenPept | |||||||||||
| RNA Seq Atlas | |||||||||||