Version 5.4
Mus musculus Gene: F2rl2
Summary
InnateDB Gene IDBG-174178.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F2rl2
Gene Name coagulation factor II (thrombin) receptor-like 2
Synonyms F730031A08; PAR3
Species Mus musculus
Ensembl Gene ENSMUSG00000021675
Encoded Proteins
IDBP-174180
coagulation factor II (thrombin) receptor-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18264801
[Homo sapiens] F2RL2 is able to signal autonomously to induce IL8 release mediated by ERK1/2 phosphorylation, which contributes actively to inflammatory responses.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164220:
This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:95696853-95702739
Strand Forward strand
Band D1
Transcripts
ENSMUST00000022182 ENSMUSP00000022182
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0015057 thrombin receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007596 blood coagulation
GO:0070493 thrombin receptor signaling pathway
Cellular Component
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164220
View Gene Order
ENSBTAG00000000898
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_231468
GPCR ligand binding pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_220322
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_21384
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
REACT_604
Hemostasis pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
nephrin_neph1_pathway
Nephrin/Neph1 signaling in the kidney podocyte
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
thrombin_par1_pathway
PAR1-mediated thrombin signaling events
erbb1_downstream_pathway
ErbB1 downstream signaling
cdc42_pathway
CDC42 signaling events
thrombin_par4_pathway
PAR4-mediated thrombin signaling events
rhoa_pathway
RhoA signaling pathway
insulin_pathway
Insulin Pathway
Cross-References
SwissProt O08675
TrEMBL
UniProt Splice Variant
Entrez Gene 14064
UniGene Mm.403792 Mm.403907 Mm.428344 Mm.440952
RefSeq NM_010170
OMIM
CCDS CCDS26702
HPRD
IMGT
MGI ID MGI:1298208
MGI Symbol F2rl2
EMBL AK135212 BC140985 U92972
GenPept AAC53137 AAI40986 BAE22460
RNA Seq Atlas 14064

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca