Version 5.4
Bos taurus Gene: CRHBP
Summary
InnateDB Gene IDBG-645164.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRHBP
Gene Name corticotropin-releasing factor-binding protein precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020202
Encoded Proteins
IDBP-697849
corticotropin-releasing factor-binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145708:
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:8038070-8052118
Strand Forward strand
Band
Transcripts
ENSBTAT00000026905 ENSBTAP00000026905
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051424 corticotropin-releasing hormone binding
Biological Process
GO:0001963 synaptic transmission, dopaminergic
GO:0002125 maternal aggressive behavior
GO:0006954 inflammatory response
GO:0007565 female pregnancy
GO:0009755 hormone-mediated signaling pathway
GO:0033554 cellular response to stress
GO:0035690 cellular response to drug
GO:0035865 cellular response to potassium ion
GO:0042445 hormone metabolic process
GO:0045055 regulated secretory pathway
GO:0048149 behavioral response to ethanol
GO:0051459 regulation of corticotropin secretion
GO:0051460 negative regulation of corticotropin secretion
GO:0071277 cellular response to calcium ion
GO:0071320 cellular response to cAMP
GO:0071356 cellular response to tumor necrosis factor
GO:0071391 cellular response to estrogen stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0097211 cellular response to gonadotropin-releasing hormone
GO:1900011 negative regulation of corticotropin-releasing hormone receptor activity
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0030141 secretory granule
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000145708
View Gene Order
ENSMUSG00000021680
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.25599
RefSeq NM_001101202
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca