InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CRHBP

Summary

InnateDB Gene

IDBG-29790.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRHBP

Gene Name

corticotropin releasing hormone binding protein

Synonyms

CRF-BP; CRFBP

Species

Homo sapiens

Ensembl Gene

ENSG00000145708

Encoded Proteins

IDBP-29794

corticotropin releasing hormone binding protein

IDBP-483996

corticotropin releasing hormone binding protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:76952713-76981158

Strand

Forward strand

Band

q13.3

Transcripts

ENST00000274368	ENSP00000274368
ENST00000506501	ENSP00000426097
ENST00000512446
ENST00000514258
ENST00000503763

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042277	peptide binding
GO:0051424	corticotropin-releasing hormone binding

Biological Process

GO:0001963	synaptic transmission, dopaminergic
GO:0002125	maternal aggressive behavior
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007565	female pregnancy
GO:0007611	learning or memory
GO:0009755	hormone-mediated signaling pathway
GO:0033554	cellular response to stress
GO:0035690	cellular response to drug
GO:0035865	cellular response to potassium ion
GO:0042445	hormone metabolic process
GO:0045055	regulated secretory pathway
GO:0048149	behavioral response to ethanol
GO:0051459	regulation of corticotropin secretion
GO:0051460	negative regulation of corticotropin secretion
GO:0071277	cellular response to calcium ion
GO:0071314	cellular response to cocaine
GO:0071320	cellular response to cAMP
GO:0071356	cellular response to tumor necrosis factor
GO:0071391	cellular response to estrogen stimulus
GO:0071392	cellular response to estradiol stimulus
GO:0097211	cellular response to gonadotropin-releasing hormone
GO:1900011	negative regulation of corticotropin-releasing hormone receptor activity
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005767	secondary lysosome
GO:0005771	multivesicular body
GO:0005874	microtubule
GO:0030141	secretory granule
GO:0030425	dendrite
GO:0031045	dense core granule
GO:0043196	varicosity
GO:0043204	perikaryon
GO:0043679	axon terminus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021680

View Gene Order

ENSBTAG00000020202

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.115617 Hs.732643

RefSeq

NM_001882

HUGO

OMIM

CCDS

CCDS4034

HPRD

08348

IMGT

EMBL

GenPept

RNA Seq Atlas