InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TRPM5

Summary

InnateDB Gene

IDBG-645193.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPM5

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000046662

Encoded Proteins

IDBP-697895

transient receptor potential cation channel, subfamily M, member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26847546

[Mus musculus] Tuft cells express Il25 and elicit group 2 innate lymphoid cells in a Trpm5-dependent manner in response to parasite colonization.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070985:
This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:49817287-49835313

Strand

Forward strand

Band

Transcripts

ENSBTAT00000064700

ENSBTAP00000056352

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005227	calcium activated cation channel activity
GO:0005267	potassium channel activity
GO:0005272	sodium channel activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport