Version 5.4
Mus musculus Gene: Trpm5
Summary
InnateDB Gene IDBG-212683.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trpm5
Gene Name transient receptor potential cation channel, subfamily M, member 5
Synonyms 9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1
Species Mus musculus
Ensembl Gene ENSMUSG00000009246
Encoded Proteins
IDBP-212685
transient receptor potential cation channel, subfamily M, member 5
IDBP-542009
transient receptor potential cation channel, subfamily M, member 5
IDBP-540948
transient receptor potential cation channel, subfamily M, member 5
IDBP-541321
transient receptor potential cation channel, subfamily M, member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 26847546
Tuft cells express Il25 and elicit group 2 innate lymphoid cells in a Trpm5-dependent manner in response to parasite colonization.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070985:
This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:143069153-143094642
Strand Reverse strand
Band F5
Transcripts
ENSMUST00000009390 ENSMUSP00000009390
ENSMUST00000148715 ENSMUSP00000121802
ENSMUST00000136602 ENSMUSP00000122685
ENSMUST00000126776
ENSMUST00000150589
ENSMUST00000146075
ENSMUST00000150867 ENSMUSP00000114302
ENSMUST00000133027
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005227 calcium activated cation channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005267 potassium channel activity
GO:0005272 sodium channel activity
Biological Process
GO:0006812 cation transport
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0045087 innate immune response (InnateDB)
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000070985
View Gene Order
ENSBTAG00000046662
Not yet available
Pathways
NETPATH
REACTOME
REACT_196640
Stimuli-sensing channels pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_227861
TRP channels pathway
KEGG
mmu04742
Taste transduction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
REACT_169333
TRP channels pathway
KEGG
hsa04742
Taste transduction pathway
INOH
PID NCI
Cross-References
SwissProt Q9JJH7
TrEMBL
UniProt Splice Variant
Entrez Gene 56843
UniGene Mm.286668
RefSeq XM_006508646 NM_020277 XM_006508645
OMIM
CCDS CCDS52462
HPRD
IMGT
MGI ID MGI:1861718
MGI Symbol Trpm5
EMBL AB039952 AF228681 AJ251835 AJ271092 AK161030 AY280364 AY280365 BC133712
GenPept AAF98120 AAI33713 AAP44476 AAP44477 BAA96877 BAE36157 CAB94717 CAC19456 CAC19457
RNA Seq Atlas 56843

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca