Version 5.4
Bos taurus Gene: IGF2
Summary
InnateDB Gene IDBG-645244.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGF2
Gene Name Insulin-like growth factor II Insulin-like growth factor II Preptin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013066
Encoded Proteins
IDBP-697936
Insulin-like growth factor IIInsulin-like growth factor IIPreptin
IDBP-697937
Insulin-like growth factor IIInsulin-like growth factor IIPreptin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167244:
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5\' region overlaps the INS gene and the 3\' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:50046626-50065230
Strand Forward strand
Band
Transcripts
ENSBTAT00000017372 ENSBTAP00000017372
ENSBTAT00000044139 ENSBTAP00000041652
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0030546 receptor activator activity
GO:0043539 protein serine/threonine kinase activator activity
Biological Process
GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0001934 positive regulation of protein phosphorylation
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0009887 organ morphogenesis
GO:0031017 exocrine pancreas development
GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0042104 positive regulation of activated T cell proliferation
GO:0043085 positive regulation of catalytic activity
GO:0043410 positive regulation of MAPK cascade
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045840 positive regulation of mitosis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051146 striated muscle cell differentiation
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:2000273 positive regulation of receptor activity
GO:2000467 positive regulation of glycogen (starch) synthase activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000167244
View Gene Order
ENSMUSG00000048583
View Gene Order
Pathways
NETPATH
REACTOME
REACT_202252
Platelet degranulation pathway
REACT_225366
IRS-related events triggered by IGF1R pathway
REACT_206584
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_212196
Hemostasis pathway
REACT_205176
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_216354
IGF1R signaling cascade pathway
REACT_212308
Response to elevated platelet cytosolic Ca2+ pathway
REACT_214353
Signal Transduction pathway
REACT_213782
Metabolism of proteins pathway
REACT_201972
SHC-related events triggered by IGF1R pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150139
SHC-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_17015
Metabolism of proteins pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_604
Hemostasis pathway
REACT_230203
Platelet degranulation pathway
REACT_224553
Hemostasis pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_247926
Metabolism of proteins pathway
REACT_235886
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
REACT_188257
Signal Transduction pathway
REACT_188220
SHC-related events triggered by IGF1R pathway
KEGG
INOH
INOH website
GPCR signaling pathway
INOH website
GPCR signaling pathway
PID NCI
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt P07456
TrEMBL B8QGI3 I3PGL3 Q2F6J1 Q2F6J2 Q2F6J3 Q2F6J4 Q2F6J5 Q2F6J6 Q2F6J8 Q2F6J9 Q862E7
UniProt Splice Variant
Entrez Gene 281240
UniGene Bt.106739 Bt.30727
RefSeq NM_174087 XM_005227270 XM_005227271 XM_005227272 XM_005227273 XM_005227274 XM_005227275 XM_005227276 XM_005227277 XM_005227278
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB099052 AY957981 BC116039 DQ298740 DQ298741 DQ298742 DQ298743 DQ298744 DQ298745 DQ298746 DQ298747 DQ298749 EU518675 HQ703509 X53553 X53867
GenPept AAI16040 ABB99965 ABB99966 ABB99967 ABB99968 ABB99969 ABB99970 ABB99971 ABB99972 ABB99973 ABD34310 ACD35247 AEX15868 BAC56542 CAA37620 CAA37861
RNA Seq Atlas 281240

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca